Extractable Nuclear Antigens

Antibodies against nuclear proteins occur in a number of autoimmune diseases.

 

Ro/SSA - Sjogren's syndrome, systemic lupus erythmatosus

 

La/SS - Sjogren's syndrome, systemic lupus erythmatosus

 

Sm - systemic lupus erythmatosus (low sensitivity, buy very high specificity)


RNP - systemic lupus erythmatosus, mixed connective tissue disease

 

centromere - CREST

 

anti-Scl 70 - systemic sclerosis (scleroderma)

 

anti-Jo1

inflammatory myositis