Systemic Sclerosis (Scleroderma)

 

 

Causes and Risk Factors

 

 

 

 

Signs, Symptoms, and Diagnosis

 

  • history
  • physical exam
  • labs

History

Esophageal fibrosis can lead to dysphagia.

Physical Exam

Can begin in hands, face, or mouth

most commonly affected systems

skin - scleroderma, calcinosis, telangiectasia, Raynaud's disease. 

lungs - interstitial lung disease, pulmonary hypertension, pleural effusions

kidneys - scleroderma renal crisis

heart - arrhythmias, pericarditis, myocardial fibrosis

Labs

 

autoantibodies include ANA, anti-centromere, anti-Scl-70, and anti-RNP

Urinalysis

micro

 

 

 

 

types of scleroderma

limited cutaneous scleroderma

vascular phenomenon tend to be grouped together: Raynaud's, telangiectasia, pulmonary hypertension

CREST syndrome

diffuse cutaneous scleroderma

often centromere antibody

 

 

 

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Pathophysiology

 

 Renal crisis 

can lead to microangiopathic hemolytic anemia:

 

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Treatments

 

 

 

 

 

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Consequences and Course

 


 

 

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The Patient

 

 

 

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Health Care Team

 

 

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Community Involvement

 

 

 

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References