Sjogren's syndrome is a chronic inflammatory disorder characterized by decreased lacrimal and salivary gland function.
It can occur in a primary form or secondary to other rheumatic conditions.
Sicca symptoms describe xeropthalmia (dry eyes) and xerostomia (dry mouth).
Can have extra-glandular involvement: skin, joints, muscles, thyroid gland, lungs, heart, GI tract, liver, kidneys, pancreas, CNS, PNS
associated increased risk of lymphoma - 16-44%
Antibodies against rheumatoid factor or extractable nuclear antigens Ro or La can be present.
Sjogren's syndrome is charactierized by lymphocytic infiltration into tissues or organs.
B cell expansion