Sjogren's syndrome

 

Sjogren's syndrome is a chronic inflammatory disorder characterized by decreased lacrimal and salivary gland function.

 

Causes and Risk Factors

It can occur in a primary form or secondary to other rheumatic conditions.

 

 

 

 

Signs, Symptoms, and Diagnosis

 

Sicca symptoms describe xeropthalmia (dry eyes) and xerostomia (dry mouth).

Can have extra-glandular involvement: skin, joints, muscles, thyroid gland, lungs, heart, GI tract, liver, kidneys, pancreas, CNS, PNS

associated increased risk of lymphoma - 16-44%

 

Antibodies against rheumatoid factor or extractable nuclear antigens Ro or La  can be present.

 

 

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Pathophysiology

 

Sjogren's syndrome is charactierized by lymphocytic infiltration into tissues or organs.

 

B cell expansion

 

 

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Treatments

 

 

 

 

 

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Consequences and Course

 

 

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The Patient

 

 

 

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Health Care Team

 

 

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Community Involvement

 

 

 

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References