Hemolytic Uremic Syndrome (HUS)

Hemolytic Uremic Syndrome (HUS) is a microangiopathic hemolytic anemia predominantly affecting children.

Causes and Risk Factors

HUS is caused by Shiga toxin, from E Coli 0157:H7. Common sources include:

Epistaxis, hematuria, hemoptysis, GI bleed

Renal failure: abnormal urinalyis, oliguria, ARF

CBC and peripheral smear

stool C and S for pathogenic cause

Plasmapheresis and steroids are the treatments of choice. Plasma infusion should be given if plasmapheresis is not immediately available.

Do NOT give platelets, as this can increase rates of intravascular thrombosis.