Eczema

Eczema is a clinical term describing many pathogenically different conditions. The Greek word eczema means "to boil over". All are characterized by red, papilovesicular, oozing, and crusted lesions which develop over time into raised, scaling plaques. Small and larger blisters (vesicles and bullae) may be present.

Over time, vesicles can become progressively scaly (hyperkeratotic) as the epidermis thickens (acanthosis).

 

Epidemiology

 

 

 

Signs and Symptoms

The itch that rashes

acute:

chronic, or secondary:

 

 

Categories of Eczematous Dermatitis

 

endogenous

exogenous (contact dermatitis)

 

unclassified

 

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Diagnosis

cultures and fungal scrapings may be done

skin biopsy apparently reveals something

allergy testing: patch tests, rast tests, prick tests

 

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Pathophysiology

 

Edema occurs within the intercellular spaces of the epidermis, primarily the stratum spinosum. Mechanical shearing of desmosomes and cell membranes by fluid accumulation results in intraepidermal vesicles.

 

Epidermal antigens are taken up by Langerhans cells, which then migrate to draining lymph nodes. Antigens are processed and presented to naitve CD4+ T cells, which are activated and develop into effector and memory T cells.

On re-exposure, these T cells migrate to affected skin sites, releasing cytokines and other factors recruiting inflammatory cells.

Early cytokine release causes venule endothelial activation, promoting memory T cell adhesion and extravasation. Expression of an array of lymphokines recruits large numbers of inflammatory cells within 24 hours. This accounts for initial erythema and pruritus acompanying cutaneous delayed hypersensitivity.

 

Chronic exposure to UV damages epidermal Langerhans cells, required for the development of contact hypersensitivity. Neuropeptides also appear to affect Langerhans cell function, suggesting implications for neural roles in the development and severity of certain dermatidites.

 

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Causes and Risk Factors

 

Local irritants more often contribute than foods - wool clothing, sand/dirt, saliva, heat/cold, dry air

 

 

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Treatments

take a really good history; ask all about what products they use

Acute:

chronic:

 

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Course

 

 

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Patient Education

 

 

 

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Community Resources

 

 

 

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