Membranous Glomerulonephropathy

Membranous Glomerulonephropathy is a chronic disease characterized by subepithelial deposition of immune complexes and basement membrane thickening. It accounts for 40% of cases of adult nephrotic syndrome and is more common in males.

 

 

Causes and Risk Factors

 

Causes are idiopathic in 85% of cases.

Secondary causes include:

 

 

 

 

 

Signs, Symptoms, and Diagnosis

 

  • history and physical exam
  • lab investigations
  • diagnostic imaging

History and Physical Exam

Signs and Symptoms include those of nephrotic syndrome.

Lab Investigations

Diagnostic Imaging

 

 

 

 

 

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Pathophysiology

Histologically, immunoglobulin deposition leads to widespread basement membrane thickening. Over time, mesangial matrix leads to glomerular hyalinization and nehron atrophy.

 

 

 

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Treatments

 

Treatments targeting the immune response include corticosteroids, cyclophosphamide, and cyclosporin.

 

Treatment of the underlying condition in secondary disease can result in remission.

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Consequences and Course

 

 

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Resources and References