Alport's Syndrome
- causes and risk factors
- signs, symptoms, and diagnosis
- pathophysiology
- treatments
- consequences and course
- the patient
- health care team
- community involvement
- resources and references
Alport's syndrome is usually X-linked, therefore affecting mainly males. Both autosomal dominant and autosomal recessive patterns of inheritance have been described.
Causes and Risk Factors
Signs, Symptoms, and Diagnosis
- history
- physical exam
- lab investigations
- diagnostic imaging
History
Physical Exam
Ocular abnormalities, including lens dislocation, cataract, and conical cornea can all occur. Sensorineural deafness is also possible.
Lab Investigations
Glomerulonephritis leads to hematuria. Platelet dysfunction and hyperproteinemia can also occur.
Diagnostic Imaging
Pathophysiology
An abnormality in collagen IV, found in the basement membranes, is found in all patients, who also lack Goodpasture's antigen.
Treatments
Consequences and Course
The Patient
Health Care Team
Community Involvement
Resources and References