Neuroradiology
Imaging Modalities
There is a tendency these days to do shotgun imaging, but this results in a lot of false positives. It is much better to let differential diagnosis, based on history, physical examination, and basic lab tests, guide your imaging investigations.
Use the modality that will rule in or out the suspected disease
plain films
the traditional opening modality
- fast, cheap, and accessible
- can be used in acute spine trauma because it can be wheeled into the room
- be sure to look down all the way to C7/T1
- also good for skull fractures
five basic X-ray densities: air, fat, water, bone, metal
CT scan
- shows scalp, skull, brain
- good for non-specifici neurological compliants
- useful for assessment of acute trauma, stroke, intracranial damage
- rules out and follows space-occupying lesions
contrast material
- useful for highlighting areas that blood pools, ie tumour
- don't use if you're looking for fresh blood, as it will obscure
- nephrotoxic, and some risk of allergic reaction
risks
- significant radiation exposure
- risks associated with contrast enhancement
- ' a single CT scan on a newborn girl has a 1:800 chance of causing a fatal cancer' - Nature editorial
ultrasound
of limited use in the brain due to the skull.
can be used in infants (with their softer skulls) or also on the carotid to look for stenosis (with doppler
angiography
- excellent resultion of small vessels, including dynamic flow
- good for characterizing vascular problems such as aneurysms, AVM
- best for picking up cerebral vasculitis
- good for endovascular therapy
risks
- invasive
- risk associated with groin puncture
- risk associated with navigation of vessels and dislodging clots
MRI
- signal comes from time of relaxation following withdrawal of energy
- T1 and T2 weighted image, based on signal decay
- water is dark in T1
- water is light in T2
- evaluates vascular, inflammatory, neoplastic, metabolic conditions
- most pathologic conditions accumulate water (edema)
contrast enhancement
- will accumulate wherever BBB is broken down
- used on a T1-weighted images
diffusion weighted images
- based on Brownian motion; picks up edema
- great for picking up strokes within a few minutes
PET