Autism Spectrum Disorder
Causes and Risk Factors
Signs, Symptoms, and Diagnosis
There is a triad of symptoms in autism.
social interaction impairments
- marked impairment in multiple nonverbal behaviour
- failure to develop peer relationships
- markedly impaired expression of pleasure in other people's happiness
- lack of social or emotional reciprocity
communication interaction impairments
- delay in/lack of spoken language, not compensated for by mime, gestures, etc
- if adequate speech, marked impairment to iniate or sustain conversation
- stereotyped, repetitive use of language
- lack of spontaneous make-belief play or social imitative play
repetitive, restrictive, or stereotyped behaviours
- encompassing preoccupation with special interests abnormal in intensity or focus
- compulsive adherence to non-functional routines or rituals
- stereotyped motor mannerisms
- persistent preocupation with parts of objects
decision-making
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Pathophysiology
Genetic and Chromosomal Abnormalities
18% of people with fragile X have autism, while 5% of people with autism have fragile X. Other chromosomal abnormalities are seen in 5% of people with autism.
The 5-HT transporter or receptor gene appears affected in some people.
Metabolism
PKU, histidinemia, Lesch Nyhan Syndrome
Infections
rubella, CMV, herpes simplex, HIV
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Treatments
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Consequences and Course
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The Patient
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Health Care Team
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Community Involvement
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References