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Hodgkin's Lymphoma
- epidemiology
- signs and symptoms
- diagnosis
- subtypes
- mutations
- causes and risk factors
- treatments
- course
- patient education
- community resources
- references
Epidemiology
bimodal age distribution
Signs and Symptoms
Typically presents with painless lymphadenopathy
nodal involvement usually follows orderly anatomic progression
Diagnosis
Reed-Sternburg cell, a B lymphocyte, is diagnostic
CBC, ESR, LDH
- CXR
- CT chest, abdomen, pelvis
- gallium scan
- bone marrow aspiration/biopsy
- excisional biopsy whenever possible
Subtypes
- Nodular sclerosing
- mixed cellularity
- lymphocyte predominant
- lymphocyte depleted
Mutations
Causes and Risk Factors
Treatments
Overall, mor ethan 75% of folks may be cured
Stage IA, IIA: radiation
Stage IB, IIB, III, IV: chemo (ABVD)
- next step: BMT
Course
Prognosis predicted by:
- stage
- presence of B symptoms (fever, night sweats, weight loss
- advanced age
- bulk disease
- certain histologies
- anemia
- elevated LDH
- elevated ESR
Patient Education
Community Resources