Celiac Disease

last authored: Oct 2009, Dave LaPierre

 

Introduction

Celiac disease, or 'gluten-sensitive enteropathy', is an allergy to the protein gluten found in wheat, barley, rye, and other grains.

 

It has an incidence of 1:80-300 in children. It usually presents at 6-18 months as wheat is introduced into the diet, but can occur at any age.

 

Celiac disease tends to be diagnosed by gastroenterologists.

 

 

The Case of...

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Causes and Risk Factors

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Pathophysiology

Allergy to gluten causes immune-mediated inflammation and destruction of absorptive villi.

 

type 0 - pre-infiltrative

type 1 - infiltrative (leukocytes)

type 2 - hyperplastic

type 3 - destructive

type 4 - hypoplastic

 

IgA is not the offending antibody

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Signs and Symptoms

 

  • history
  • physical exam

History

failure to thrive in infants and children

fatigue, irritability

diarrhea, steatorrhea

nausea, vomiting, abdominal pain

edema

weight loss

vitamin deficiency

iron deficiency (absorbed in the duodedum)

Physical Exam

Wasted muscles, distended abdomen, flatt buttocks

clubbing

rickets

 

non-GI manifestations (edit this list)

neuropsychoatric disorders - depression, psychosis

arthritis

osteoporosis

hyposplenism

dermititis herpetiformis

diabtetes

IgA deficiency

Down's syndrome

liver disease

thyroid disease

 

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Investigations

  • lab investigations
  • diagnostic imaging

Lab Investigations

anemia can be present

 

tissue transglutaminase (tTG) (95% sensitivity and specificity)

  • if the test is positive, refer the patient for small bowel biopsy

other antibodies: antigladin, antiendomyseal

fat malabsorption studies

small bowel biopsy (scope and 4-6 biopsies)

 

Diagnostic Imaging

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Differential Diagnosis

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Treatments

Diet modification

wheat, rye, barley, and perhaps oats must be avoided, for life in some cases.

inadvertent contamination can be a big problem

 

address nutritional deficiencies

iron, B12

in severe cases, calcium, magnesium, and electrolytes

 

 

monitor response

role of tTG screening is not known

biopsy should be repeated in 6-12 months

 

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Consequences and Course

Complications include:

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The Case of...

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Additional Resources

CeliacStories.ca

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Topic Development

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