Incretin

Incretins (GLP-1 and GIP)

 

 

Function

 

pancreas: glucose-dependent insulin secretion and decreased glucagon secretion

muscle and adipose tissue: increased insulin sensitivity, leading to increased glucose uptake and storage

heart: cardioprotection and increased cardiac output

liver: decreased glucose production

brain: increased neuroprotection and decreased appetite

stomach: delay gastic emptying - increased satiety and weight loss

 

 

Regulation of Expression

Released from GI tract in respose to...

DPP-IV degrades GLP-1; inhibiting it increases incretin action

 

 

Consequences of Overexpression

 

 

Consequences of Underexpression

 

 

Clinical Uses

Incretin analogues, as well as DPP-IV inhibitors, are used as hypoglycemic agents for treatment of diabetes

 

 

 

Signalling Pathways

 

 

Structure