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Valproic acid
Epival
- uses
- mechanism
- dose and half-life
- adverse drug reactions
- counter-indications and drug interactions
- metabolism and excretion
- dependency
Uses
- anti-seizure medication
- mood stabilizer
Mechanism
- cells
- proteins
Dose and Half Life
Adverse Drug Reactions
- can cause thrombocytopenia or inhibit platelet aggregation, potentially leading to increased bleeding
- hair loss, weight gain
- CNS problems: sedation, cognitive blunting
- increases liver enzymes
- polycystic ovary syndrome
~11% rate of congenital malformations; spina bifida and neural tube defects, heart defects, IUGR
Counter-Indications and Drug Interactions
- ASA, used regularly for analgesia, can reduce valproic acid elimination
- combination with
Metabolism and Excretion