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Tacrolimus
- uses
- mechanism
- dose and half-life
- adverse drug reactions
- counter-indications and drug interactions
- metabolism and excretion
- dependency
Uses
- immunosuppression
- reduces acute rejection
- steroid-sparing
Mechanism
Inhibits calcinurin, preventing transcription of IL-2 and thereby T cell activation.
Dose and Half Life
Adverse Drug Reactions
- evidence of higher renal toxicity, glucose intolerance, diabetes, cf cyclosporine
- hypertension
long term
Counter-Indications and Drug Interactions
Metabolism and Excretion
Dependency
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