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Methotrexate
Methotrexate is a drug that inhibits folic acid synthesis. It is used as an anticancer drug and an immunosupressant.
- uses
- mechanism
- dose and half-life
- adverse drug reactions
- counter-indications and drug interactions
- metabolism and excretion
- dependency
Uses
- cancer
- autoimmune disorders
- rheumatoid arthritis
- psoriasis
- medical abortions
Mechanism
- competitively and reversibly inhibits dihydrotetrafolate reductase (DHFR), an enzyme in the folate synthesis pathway
- Folate is required for thymidine synthesis
Dose and Half Life
Adverse Drug Reactions
- anemia
- neutropenia
Counter-Indications and Drug Interactions
- highly teratogenic
- risk of interaction with penecillin
Metabolism and Excretion