Clopidogrel (Plavix)

Clopidogrel is an anti-thrombotic agent. It reduces platelet aggregation by inhibiting the ADP pathway active in hemostasis.

Uses

Clopidogrel irreversibly blocks the ADP receptor in platelets, preventing aggregation.

In patients with MI, initiate early, with 300 mg loading dose and 75 mg once daily

omit 300 mg loading dose in STEMI patients over 75 years receiving thrombolyitc therapy

optimal duration of therapy is controversial, typically 1-12 months

There is a small but significant decrease in death and adverse events when given in addition to aspirin in ACS.