Local anesthetics are used to block nerve conduction, preventing pain sensation. They are used for minor procedures.
Local anesthetics can be used in place of general anesthetic to reduce nausea and vomiting, decrease cardiovascular risk, encourage earlier hospital discharge.
Local anesthetics are used for minor procedures, such as wound exploration and cleaning, suturing, fracture reduction, and excisions.
They can also be used intraoperatively to reduce pain during recovery.
Anesthetics with epinephrine are very useful for reducing bleeding at the site of injection via vasoconstriction. This can be especially helpful when attempting to visualize the field of view. Epinephrine also keeps the anesthetic local, allowing greater doses to be given by reducing the risk of systemic adverse events.
amides: generic drug names have two I's
ester: generic drug has only one I
amide
ester
One can also give lidocaine and bupivicaine mix to provide rapid onset and longer duration.
Lidocaine can be quite painful subcutaneously; bicarbonate can be given at a 1:10 ratio. Slower injection can also help with pressure
© 2006-2007 PocketSnips, Northern Ontario School of Medicine. (www.pocketsnips.org)
Video: Injection of Local Anesthetic. Used with permission.
The video is not a substitute for medical advice." |
SIMPLE - single injection median palmar lidocaine with epinephrine.
SIMPLE digital block, injected into proximal crease just above bone
Dorsal block
Used for fractures; inject directly into the fracture hematoma. Often used by emergency room physicians and orthopedics, often under conscious sedation.
Anesthesia can do a brachial plexus block, under local anesthesia and with ultrasound guidance.
People can be allergic to esters, but not amides. People CAN be allergic to the preservative in amides.
Lidocaine can be given at 7 mg/kg with epinephrine, or 5 mg/kg without.
It can be given in 1% or 2% solutions.
Local anaesthetics are lipid soluble and so can cross the BBB
As such, it is a good idea to keep local anaesthetics local!
Sigificant side effects can occur with lidocaine overdose, such as:
Lidocaine overdose can be lethal following autonomic instability.
There is no antidote for lidocaine, but there is for epinephrine.
Esters are rapidly metabolized by blood esterases, so have a short half-life.
Amides are hydrolyzed in the liver, so longer/more varied half-life.
created: DLP, Aug 09
authors: DLP, Aug 09
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