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Cefazolin
first generation cephalosporin
- uses
- mechanism
- dose and half-life
- adverse drug reactions
- counter-indications and drug interactions
- metabolism and excretion
- dependency
Uses
- gram positive cocci (not MRSA)
- drug of choice for surgical prophylaxis
- does not cross BBB
Mechanism
- binds to PBPs
Dose and Half Life
- half-life: 90-150 minutes
- IV or IM
Adverse Drug Reactions
short term
- allergic reaction possible
- local irritation, thrombophlebitis
- renal toxicity
long term
Counter-Indications and Drug Interactions
Metabolism and Excretion
- minimally metabolized in liver
- excreted in urine