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Buspirone
A sedative-hypnotic
- uses
- mechanism
- dose and half-life
- adverse drug reactions
- counter-indications and drug interactions
- metabolism and excretion
- dependency
Uses
- have anti-anxiety effetcs without sedative, euphoric, hypnotic, or psychomotor effects
- can take more than a week for anxiety to get better; with peak effect at 4-6 weeks
- can't be used PRN
- minimal potential for abuse
- doesn't potentiate effects of alcohol or TCAs
- can be combined with antidepressants to augment their effect
Mechanism
- 5-HT 1A receptor agonist
- also DA D2 receptor
- buspirone metabolite inhibits α2, leading to increased NE release
Dose and Half Life
Adverse Drug Reactions
short term
- nausea, headache, dizziness, tension, restlessness, insomnia
- tachycardia, palpations, nervousness, gi distress, paresthesia
long term
Counter-Indications and Drug Interactions
- haloperidol, MAOIs
Metabolism and Excretion
- undergos extensive 1st pass metabolism