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Azithromycin (Zithrovax)
macrolide antibiotic, derived from erythromycin
- uses
- mechanism
- dose and half-life
- adverse drug reactions
- counter-indications and drug interactions
- metabolism and excretion
- dependency
Uses
- good against T. gondii
- chlamydia
- H. influenza
Mechanism
- penetrates tissues well, with [tissue] : [serum] 100x
- proteins
Dose and Half Life
- half life of over 3 d (due to tissue reserve) leads to once daily dosing
Adverse Drug Reactions
short term
- GI, headache, ototoxicity
long term
Counter-Indications and Drug Interactions
- decreased drug interactions cf erythromycin
Metabolism and Excretion
- limited metabolism
- mostly bile