Somatostatin
Somatostatin
- functions
- regulation of expression
- consequences of overexpression
- consequences of underexpression
- signalling pathways
- structure
Function
Somatostatin inhibits the release of growth hormone from the anterior pituitary.
Regulation of Expression
- cells that express:
- tissue distribution:
- temporal expression:
Consequences of Overexpression
Overexpression of PRL (hyperprolactinemia) can lead to galactorrhea
Consequences of Underexpression
Signalling Pathways
Both PRL and GH have similiar affinities for the PRL receptor.
Structure
Prolactin is a 199 amino acid hormone with 16% homology to growth hormone.