Niacin (Nicotinic Acid)

Niacin is an essential component of NAD and NADP.

 

 

 

daily requirements

 

 

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sources

 

 

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biological roles

NAD serves as a coenzyme for a variety of dehydrogenation reactions involved in the meatabolism of fat, carbohydrates, and amino acids.

 

NADP is involved in other dehydrogenation reactions, particularly those in the hexose-monophosphate shunt of glucose metabolism.

 

In pharmacologic doses, niacin is used in treating hypercholesterolemia. It acts to lower plasma LDL levels by reducing hepatic synthesis of VLDL and ApoB.

 

 

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deficiency

 

Pellagra- dermatitis, diarrhrea, dementia.

 

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overdose

 

Can cause flushing, itching, headache

hepatotoxicity, GI problems

peptic ulcer activiation

hyperglycemia and reduced insulin activity

 

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Resources and References

 

Knopp RH. N Engl J Med 1999;341:498-511