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Interleukin-10 (gene name)

Il-10 appears to play an inhibitory role in inflammation

• Expression
• Function
• Interactions and Signalling
• Role in Disease
• Structure
• Gene and Processing

Expression

• cells that express: CD4+ cells (Th2 subtype)
• tissue distribution:
• temporal expression:

Function

• acts on macrophages to inhibit cytokine production, reducing the CD4+ response
• downregulates MHC II expression on APCs

Interactions and Signalling

• receptor:

Role in Disease

• deficiency may be involved in allergic bronchopulmonary aspergillosis (ABPA)

Structure

• template

Gene and Processing

• PubMed ref: here
• other info