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Catechol-O-methyl-transferase (COMT)
COMT is an enzyme involved in the breakdown of monoamine neurotransmitters, including norepinephrine and dopamine.
- Introduction
- Function
- Expression
- Interactions and Signalling
- Role in Disease
- Structure
- Gene and Processing
Introduction
Function
- inactivates monoamines, working together with LAAD and MAO
Expression
- present in high levels in endothelial cells, the heart, liver, and kidneys
Interactions and Signalling
- receptor:
Role in Disease
- appears to increase risk of schizophrenia, especially the Val/Val
Structure
- template
Gene and Processing
- PubMed ref: here
- other info