Antiviral drugs target specific virus molecules and mechanisms.
M2 ion channel inhibitor, blocking viral uncoating and RNA transscription. Influenza A only
Prophylaxis. 60-70% effective in preventing infection in institutionalized
Side effects: agitation, confusion, loss of balance, nausea and vomiting
Increased resistance among many Influenza
High-affinity for active site of NA, preventing spread of virus particles from cell to cell
Active against influenza A and B. Effective against all strains, though resistance is an increasing issue.
excreted in urine
Mono-phosphorylated by thymadine kinases to inhibit viral DNA polymerase.
Acyclovir: low oral bioavailability.
Side effects: worse with IV use.
appears to be safe in pregnancy
Resistance (thymadine kinase mutations) increasing in patients with AIDS, or transplant patients.
developed to target CMV
inhibitory for all herpesviruses
toxicity is a subsantial problem; avoid if possible