Gastrointestinal Conditions and Diseases

 

Due to constant mechanical trauma and exposure to pathogens and toxic substances, the gastrointestinal system experiences substantial damage over a lifetime. Gastrointestinal concerns are extremely common, with many of these listed below.

  • Esophagus
  • Stomach
  • Intestines
  • Liver
  • Pancreas
  • Gall Bladder

 

Esophageal Conditions and Diseases

Other

Zencker's diverticulum is a failure of UES relaxation. It is most common in older people with neurological issues such as stroke or Parkinson's.

 

Diffuse esophageal spasm occurs with disordered esophageal spasm.

 

Nutcracker esophagus is a high pressure esophageal state with peristalsis.

 

Scleroderma relaxation of the LES with free reflux up the esophagus, along with motor dysfunction.

 

Boerhaave's - rupture of the GE junction from violent vomiting. Fix the problem and place a number of drains and chest tubes to remove food from the paraesophageal space. The earlier the surgery, the more successful it should be. Suture the mucosa as well as the musculature.

Small perforations can be treated conservatively if food leaks back into the esophagus.

 

Stomach Conditions and Diseases

 

Intestinal Conditions and Diseases

to clean up:

Small Intestine

The small intestine is colonized with many bacteria, fungi, and parasites. Most of these are anaerobes, such as Peptostreptococcus, Porhyromonas, and Prevotella. Small numbers of Samonella and Campylobacter can be present asymptomatically. Intestinal stasis can lead to colonization and invasion by organisms normally associated with the colon, leading to malabsorptive syndromes.

 

Large Intestine

More microbes are found in the large intestine than anywhere else in the body - it is estimated that there are more than 1011 bacteria per gram of stool. Anaerobic bacteria are in excess of more than 1000 fold, with the most common being Bifidobacterium and Eubacterium. These bacteria rarely cause disease.

While enterobacteriacae such as Escherichia coliaccount for less than 1% of the bacterial population, it accounts for most intra-abdominal disease.

Various yeasts and non-pathogenic parasites also are present.

Antibiotic treatment can rapidly change the bacterial population in the colon, leading to proliferation of antibiotic-resistant organisms such as Pseudomonas, enterococci, fungi, and C. difficile.

 

 

Pathogenesis

Viral gastroenteritis is one of the top 5 causes of pediatric admission to hospital.

There are now dipsticks available to screen stool for rotavirus, adenovirus, and norovirus, wher

adenovirus can cause diarrhea

 

 

Pancreas Conditions and Diseases

 

 

 

Additional Resources

 

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