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Splenomegaly
Splenic enlargement can be an important clue to the presence of underlying disorders but can also cause problems itself. Any c
It can produce a dragging sensation in the left upper quadrant and discomfort after eating.
Splenic enlargement can lead to the sequestration of all blood cells, leading to anemia, thrombocytopenia, and leukopenia.
Causes of Splenomegaly
There are various possible causes of splenomegaly, including:
Chronic intravascular infection/inflammation
infections
- infectious mononucleoisis
- tuberculosis
- malaria
- endocarditis
- etc
congestive states related to portal hypertension
- liver cirrhosis
- portal or splenic vein thrombosis
- cardiac failure
lymphohematogenous disorders
- Hodgkin's lymphoma
- non-Hodgkin's lymphoma
- lymphocytic leukemias
- multiple myeloma
- myeloproliferative disorders
- hemolytic anemias
- thrombocytopenic purpura
autoimmune conditions
- rheumatoid arthritis
- systemic lupus eryhtmatosus
storage diseases
- Gaucher disease
- Niemann-Pick disease
- mucopolysaccharidosis
other
- amyloidosis
- primary neoplasms and cysts
- secondary neoplasms