Alpha Agonists
Alpha agonists are described under vasopressors and inotropes.
Adrenoreceptor Antagonists
Centrally acting act on the BP control centre in the brain. It is thought that they act on α2 receptors to inhibit NE release
- side effects include sedation
Beta-blockers
- decrease cardiac output (both HR and contractility)
- also decrease renin release, leading to lowered Na, water retention and vasodilation
- makes exercise difficult
Drugs
- propanolol: β1 and β2 antagonist
- metoprolol: β1 antagonist
- atenolol
- acebutamol
- bisoprolol
Uses
Mechanism(s)
- competitively inhibits beta1 receptors reducing HR, contractility, BP, and MVO2
- increases duration of diastole
- increased preload
- profound fatigue
- loss of glycemic control
- impotence
- contraindicated in asthma
- decreases heart rate
- decreases contractility
- decreases afterload
Adverse Effects
increasing doses of beta blockers causes loss of cardioselectivity.
short term
- avoid acute adminstration in unstable patients with hypotension or overt HF
- bradycardia and heart block
- bronchospasm
- peripheral vasoconstricion
- fatigue, lethargy
long term
- depression, vivid dreams, nightmares
Contraindications
- absolute: asthma
- relative:
- tendency to bronchospasm
- insulin dependent T2DM
- conduction system disease
- peripheral vascular disease