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ECF osmolality can be approximated using the major solutes: (2 x sodium) + (glucose / 18 ) + (BUN / 2.8)
Measured osmolality usually equals the calculated osmolality. However, if other osmotically active substances are present, the measured value will be higher, and the osmolality gap suggests the presence of toxins.
Causes of Osmolar Gap
Methanol, mannitol
Alcohols: ethanol, isopropanol
Dyes
Glycols, glycerol
Acetone
Sorbitol
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created: DLP, Aug 09
authors: DLP, Aug 09
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