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Delayed-Type Hypersensitivity
Dealyed type hypersensitivity (DTH), also called Type IV hypersensivity, takes 24-48 hours to occur.
DTH is a cell-mediated response in which APCs present antigen to memory CD4+ Th1 cells, causing rapid expression of interferon-gamma and inducing angry macrophage transformation.
The best-known example of DTH is the response to M. tuberculosis during the Mantoux skin test.