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Incidence of 3-4 cases/million each year.
a simple case introducing clincial presentation and calling for a differential diagnosis to get students thinking.
Pituitary adenomas are behind 95% of cases of acromegaly. Other causes include:
Suppression test can be used.
Random GH, if low, can exclude acromegaly, but is not useful as a routine test.
IGF-1 and IGFBP-3 can also be useful.
surgery
radiotherapy
somatostatin analogues
DA agonists
GH receptor antagonists
Cardiovascular disease accounts for over half of acromegaly deaths.
Conditions that can also occur include:
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