Global Developmental Delay

last authored:

 

 

Introduction

Global developmental delay, also known as mental retardation, or intellectual disability, is defined by three components:

It affects 1% of the population, with males slightly more affected.

 

Ensure you are using language patients and families respond best to.

 

Mild: 2-3 SD below

Moderate: 3-4 SD

Severe: 4-5 SD

Profound: >5 SD

 

 

 

The Case of...

a simple case introducing clincial presentation and calling for a differential diagnosis. To get students thinking.

return to top

 

 

 

Causes and Risk Factors

Causes of GDD are many, and include:

genetic:

  • Down syndrome
  • Fragile X syndrome
  • PKU

prenatal

  • rubella
  • fetal alcohol syndrome
  • heroin, cocaine exposure
  • TORCH infections
  • HIV
  • maternal diabetes
  • toxemia
  • maternal malnutrition
  • birth trauma or hypoxia

perinatal

  • prematurity
  • cerebral ischemia
  • intracranial hemorrhage
  • maternal deprivation
  • hypothyroidism

childhood

  • intracranial infection
  • head trauma
  • failure to thrive
  • lead poisoning

Other risk factors for mild GDD include low SES, parental neglect, teen pregnancy, or family violence.

return to top

 

 

 

Pathophysiology

return to top

 

 

 

Signs and Symptoms

  • history
  • physical exam

History

 

Physical Exam

 

return to top

 

 

 

Investigations

  • lab investigations
  • diagnostic imaging

Lab Investigations

Diagnostic Imaging

return to top

 

 

 

Differential Diagnosis

return to top

 

 

 

Treatments

The main goal of treatment is to enhance level of functioning, as well as to support parents.

Community-based treatment is preferred over institutionalization when preferred.

Education can be targeted at life skills, vocation, communication, and family dynamics.

Therapy can be individual or family, and is often targeted at disruptive behaviours.

return to top

 

 

 

Consequences and Course

return to top

 

 

 

Resources and References

return to top

 

 

 

Topic Development

authors:

reviewers:

 

return to top