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T Cell Receptor (gene name)

Add brief intro here

• Expression
• Function
• Interactions and Signalling
• Role in Disease
• Structure
• Gene and Processing

Expression

• T Cell Receptor is expressed by T Lymphocytes
• Different combinations of TCR are present on different T cell populations; over 95% of T cells express the αβ TCR

Function

• TCR recognizes antigen presented on MHC I or II molecules. Contact results in T cell activation

Interactions and Signalling

• TCR present on the cell surface interacts with antigen presented on MHC I and II molecules.
• Polyclonal TCRs can be activated by superantigens, resulting in a cytokine storm
• Signal transduction following TCR activation involves CD3 and ZAP70, amongst many others.

Role in Disease

• if any

Structure

• TCR is composed of two chains. The alpha chain is similar to immunoglobin Heavy chain, while the beta chain is similar to the Light chain.

Gene and Processing

• TCR are produced by gene rearrangement of VDJ regions, involving the Rag protein.
• PubMed ref: here
• other info