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Plasmin (gene name)

Plasmin is a potent proteolytic enzyme that breaks down fibrin clots

• Expression
• Function
• Interactions and Signalling
• Role in Disease
• Structure
• Gene and Processing

Expression

• Plasminogen is a plasma protein produced by liver?
• Plasminogen is converted into plasmin in two ways:
  • by tPA - tissue plasminogen activator
  • by Hageman Factor (Factor VII) pathway during inflammation

 

Function

• plasmin breaks down fibrin clots
• fibrin clot particles induce neutrophil chemotaxis
• plasmin contributes to the activation of the classical complement pathway

Interactions and Signalling

• receptor:

Role in Disease

• if any

Structure

• template

Gene and Processing

• PubMed ref: here
• other info