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Interleukin-2 Receptor (gene name)

Interleukin-2 Receptor (IL-2 R) is the receptor for interleukin-2 (IL-2).

• Expression
• Function
• Interactions and Signalling
• Role in Disease
• Structure
• Gene and Processing

Expression

• Activated T cells express approximately 5 x 10³ high affinity receptors and ten times as many low affinity receptors.
• NK cells express beta and gamma subunits, allowing them to bind and respond to IL-2 with intermediate affinity.

• tissue distribution:
• temporal expression:

 

The IL-2 receptor is composed of alpha, beta, and gamma subunits. The alpha chain is only expressed by activated T cells, and binding to IL-2 will only occur with high affinity with a trimeric receptor.

Function

• IL-2 R signalling induces T cell proliferation.
• Regulation of alpha chain expression ensures that only activated CD4+ and CD8+ cells proliferate in response to physiologic levels of IL-2.

Interactions and Signalling

• receptor:

Role in Disease

• if any

Structure

• template

Gene and Processing

• PubMed ref: here
• other info