Statins are lipid-lowering drugs used in patients with high cholesterol, both pre-and post-myocardial infarction.
Doubling a dose of statins decreases the LDL by 6%.
Statins reduce hepatic cholesterol synthesis, lower intrcellular cholesterol, stimulate LDL uptake. The net effect is to decrease LDL levels in the blood. Decreases oxidative stress; leads to plaque stability.
Further reductions in LDL cholesterol safely produce definite further reductions in the incidence of heart attack, of revascularisation, and of ischaemic stroke, with each 1·0 mmol/L reduction reducing the annual rate of these major vascular events by just over a fifth. There was no evidence of any threshold within the cholesterol range studied, suggesting that reduction of LDL cholesterol by 2-3 mmol/L would reduce risk by about 40-50%. (CTT, 2010).
Cholesterol Treatment Trialists’ (CTT) Collaboration et al. 2010. Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials. Lancet. 376(9753):1670-81.