Post-Transplantation

Post-Transplantation Risks

Reactivation of latent infections/colonization

Viruses that may remain latent include herpes zoster, cmv, hpv, ebv and others.

Bacteria include tuberculosis.

Fungi?

Parasites?

Toxoplasma gondii infection may be a serious problem.

Immunosupressive Therapy

Three drug types used to inhibit innate, humoral, and cell-mediated immunity.

slowing proliferation of activated B and T cells (S phase inhibitors)

corticosteroids (anti-inflammatory effects - cytokines)

cyclosporin A, FK 506, rapamycin - inhibit IL-2 transcription, bloccking T cell proliferation and activation

following surgery, there will be the multiple breaks in the skin at the surgical site, as well as the multiple lines and catheters inserted.