General pathology concepts apply to most or all diseases to varying degrees.
WebPath is a great online resource for examples of pathology, both gross and histological.
Granulomas are congregations of macrophages and lymphocytes that develop in various settings of chronic inflammation, including M tuberculosis infection and Crohn's disease
form from antibody-antigen binding
if not cleared by phagocytosis, can be deposited in tissues
Can be caused by
persistent, low grade bacterial, viral, parasitic antigens
repeated inhalation of antigens from molds, plants, animals
Symptoms typically appear days to weeks after antigen exposure
Raji Cell Test
Raji Cells are derived from Burkitt's lymphoma and express both Fc IgG receptors and complement receptors
It is used to detect immune complexes
Dealyed type hypersensitivity (DTH), also called Type IV hypersensivity, takes 24-48 hours to occur.
The best-known example of DTH is the response to M. tuberculosis during the Mantoux skin test.