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Interleukin-6 (gene name)

IL-6 is an important regulator of inflammation, both local and systemic.

• Expression
• Function
• Interactions and Signalling
• Role in Disease
• Structure
• Gene and Processing

Expression

• cells that express: CD4+ cells, (Th2 subtype) monocytes, macrophages, bone marrow cells
• tissue distribution:
• temporal expression:

Function

• stimulates hepatocytes to make acute phase proteins, such as C-reactive protein
• acts on B cells to promote differentiation into plasma cells
• found in sites of inflammation
• induces fever

Interactions and Signalling

• receptor:

Role in Disease

• if any

Structure

• template

Gene and Processing

• PubMed ref: here
• other info