Interleukin-1 (gene name)
Interleukin-1 (IL-1)
Expression
- cells that express: macrophages, monocytes, dendritic cells
- presence of microbial products induces IL-1 expression by macrophages
Function
- increases endothelial activation
- increases vascular permeability
- chemotactic for...?
- induces fever by working on thermal regulatory centre in hypothalamus (endogenous pyrogen)
- acts as a co-stimulator for CD4+ cells
- promotes B cell maturation and proliferation
Interactions and Signalling
- receptor:
Role in Disease
- if any
Structure
- template
Gene and Processing
- PubMed ref: here
- other info