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Human Leukocyte Antigens (gene name)

HLAs, or human leukocyte antigens, are a group of highly polymorphic proteins that represent the human equivalent of MHC class I and II molecules.

• Expression
• Function
• Interactions and Signalling
• Role in Disease
• Structure
• Gene and Processing

Expression

• cells that express:
• tissue distribution:
• temporal expression:

Function

HLA molecules bind fragments of peptide antigens for recognition by T cells. During infection, pathogen-derived peptides are presented.

 

Interactions and Signalling

• receptor:

Role in Disease

During transplantation, T cells encounter 'foreign' HLA proteins on donor cells and attack the cell. Even matched HLA molecules can present other unmatched peptides, triggering host immune response.

 

Structure

• template

Gene and Processing

• PubMed ref: here
• other info