Abl

Introduction to Abl

Abl is a tyrosine kinase rsponsible for...

It does something in the nucleus, I think

Abl Structure

Abl fabl.

Abl and Cancer

Abl is half the reason that the Philedelphia chromosome was discovered. This chromosomal translocation results in a fusion protein betwen Bcr and Abl.

Gleevec, or imatinib, was one of the first drugs designed with a specific protein target in mind.